Calcium Signalling and Disease - Molecular Pathology of by Editors: Ernesto Carafoli and Marisa Brini

By Editors: Ernesto Carafoli and Marisa Brini

Authors spotlight a number of promising discoveries within the box of calcium signaling that offer new information regarding either genetic and bought pathologies. Their discussions provide you with new insights into the underlying reasons of congenital and purchased ailments and element how you can new, much more promising examine and cures.

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Am J Rhinol. 19(5): 483–7. A. Israel, 1992, Developmental regulation of annexin II (Lipocortin 2) in human brain and expression in high grade glioma. Cancer Res. 52(24):6871–6. A. Israel, 1994, Annexin II marks astrocytic brain tumors of high histologic grade. Oncol Res. 1994;6(12):561–7. , and J, Carlstedt-Duke, 1988, Relation between defective regulation of arachidonic acid release and symptoms in cystic fibrosis. Scand J Gastroenterol Suppl. 143:1–4. A Noegel, 1995, Expression and localization of annexin VII (synexin) in muscle cells.

Cancer Res. 52(24):6871–6. A. Israel, 1994, Annexin II marks astrocytic brain tumors of high histologic grade. Oncol Res. 1994;6(12):561–7. , and J, Carlstedt-Duke, 1988, Relation between defective regulation of arachidonic acid release and symptoms in cystic fibrosis. Scand J Gastroenterol Suppl. 143:1–4. A Noegel, 1995, Expression and localization of annexin VII (synexin) in muscle cells. J. Cell Sci. 108 (Pt 1), 85–95. , Miller, S. , Loughrey, C. , Meyers, M. B. L. Smith, 2003, Effects of adenovirus-mediated sorcin overexpression on excitation-contraction coupling in isolated rabbit cardiomyocytes.

1999). The function of the autoproteolytic step is thus still unclear. 5. REGULATION OF CALPAIN ACTIVITY. THE CALCIUM REQUIREMENT PROBLEM The calcium concentrations required for the activity of - and m-calpains are much higher than the 50–300 nM found in the cytosol of living cells. Efforts have thus been made to identify possible mechanisms to reduce the calcium requirement of the calpains, focusing on factors that might act as “activators”. , 1992). Very high molar ratios of the phospholipids were required, making it unlikely that this mechanism would function under physiological conditions.

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