By A.H. Rose and J. Gareth Morris (Eds.)
This quantity in a research-level sequence covers diversified features of microbial body structure and biochemistry together with inositol metabolisms in yeasts, bacterial adhesion, natural acids, the bacterial flagellum and the mechanical behaviour of bacterial phone partitions. it really is meant to be of use to microbiologists, biochemists and biotechnologists. different similar works during this sequence are volumes 29, 30 and 31.
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Additional info for Advances in Microbial Physiology, Vol. 21
1974a). European Journal ofBiochemistr). 44. 407. , Sauer, H. W. and Braun, R. Biochimica et Biophysica Acta 353, 3 13. , Sauer, H. W. and Scheller, K. JournulofCell Science 18, 27. , Sauer, H. and Scheller, K. (1975b). Archives of Biochemistry and Biophysics 168, 273. Funderud, S . and Haugli, F. ( 197 7). ~physicalResearch Communications 74,94 1. Goodman, E. M. JounalofBactenology 111, 242. Goodman, E. , Sauer, H. , Sauer, L. and Rusch, H. P. Canadian Journal of MicrobioloRy 15, 1325. Gornicki, S.
In contrast, the transcriptional activity during t:he first peak is sensitive to a-amanitin (Davies and Walker, 1977, 1978). Taken together, these observations suggest that during the first peak of activity (S-phase) it is chiefly RNA polymerase I1 which is active and, hence, it is messenger RNA which is predominantly synthesized; during the second peak (G2phase), the predominant activity is that of RNA polymerase I synthesizing ribosomal RNA. A). This demonstrated in both cases that RNA synthesized during the S-phase peak of activity has a rather DNA-like base composition (as would be expected for messenger RNA), while RNA synthesized during the G2-peak has a higher GC-content and hence bears more resemblance to ribosomal RNA.
Furthermore, studies of the transcription of unique sequence DNA strongly suggest that there are qualitative as well as quantitative differences between the RNA populations synthesized during S-phase and G2-phase (Fouquet and Braun, 1974). There may be about three times more different sequences transcribed in S-phase than in G2-phase. Taking all these results together it is clear that there is a control over both the type and the quantity of RNA transcribed during the mitotic cycle. This implies the existence of a transcriptional programme which gets repeated with every cell cycle.